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trimebutine maleate + Clostridium butyricum
- Development stage
- Unknown
- Lead developer
- Hainan Poly
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
This is a combination drug consisting of trimebutine maleate, a gastrointestinal motility modulator, and Clostridium butyricum, a probiotic bacterium. Trimebutine maleate acts as a non-competitive spasmolytic agent with mild opioid receptor affinity and significant anti-serotonin activity. It regulates gastrointestinal motility by exerting both stimulatory and inhibitory effects on intestinal smooth muscle, making it effective for treating symptoms of irritable bowel syndrome (IBS), including abdominal pain, bloating, diarrhea, and constipation[2][4][5]. Clostridium butyricum is an anaerobic gram-positive bacillus used as a probiotic to restore gut flora balance. It produces butyrate—a short-chain fatty acid essential for colon health—supports the integrity of the gut barrier, inhibits pathogenic bacteria growth through bacteriocin production, enhances nutrient absorption, and modulates immune responses[6][8]. The combination targets both functional dysregulation (via trimebutine) and microbiota imbalance (via C. butyricum), providing comprehensive management for gastrointestinal disorders such as IBS-D (diarrhea-predominant IBS)[1].
- Other names
- 马来酸曲美布汀 + 酪酸梭活菌
02
Targets
5-HT (Serotonin receptors)FFAR3 (Free fatty acid receptor 3)MOR (Mu opioid receptor)
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