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triprolidine + pseudoephedrine
- Development stage
- Unknown
- Lead developer
- LIFEPharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Coldifed is an orally administered combination medication developed and manufactured by LIFEPharma for the symptomatic relief of the common cold, cough, and allergic rhinitis. It contains two active small molecule ingredients: triprolidine hydrochloride and pseudoephedrine hydrochloride. Triprolidine is a first-generation antihistamine that functions as a selective antagonist of the histamine H1 receptor, reducing symptoms like sneezing and rhinorrhea. Pseudoephedrine is a sympathomimetic amine that acts as a decongestant by stimulating alpha-adrenergic receptors in the respiratory tract mucosa, leading to vasoconstriction and reduced nasal congestion. The product is approved for marketing and is available in various formulations, including tablets and syrups, primarily in the Middle East region.
- Brand names
- Coldifed
- Other names
- triprolidine hydrochloride + pseudoephedrine hydrochloride
02
Targets
HTR7 (5-hydroxytryptamine receptor 7)ADRA1A (α1A)DAT (Dopamine plasma membrane transport protein)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)NET (Norepinephrine Transporter)ADRA1 (Alpha-1 adrenergic receptor family)
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