triptorelin + chemotherapy

Triptorelin + chemotherapy refers to a treatment regimen combining triptorelin, a gonadotropin-releasing hormone (GnRH) agonist, with chemotherapy. This combination is primarily used as an adjuvant treatment for hormone-responsive early-stage breast cancer in premenopausal women at high risk of recurrence, particularly those who remain premenopausal after chemotherapy. Triptorelin suppresses ovarian function, reducing estrogen levels, which aids in controlling hormone-dependent cancer growth. Clinical trials like SOFT and TEXT have demonstrated that adding triptorelin (for ovarian function suppression) to endocrine therapy (tamoxifen or aromatase inhibitors) provides significant disease control benefits, especially in higher-risk patients post-chemotherapy. Additionally, triptorelin may be used with chemotherapy for fertility preservation in premenopausal women receiving curative treatment for cancer.