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triticum vulgare aqueous extract + polyhexanide
- Development stage
- Unknown
- Lead developer
- Farmaceutici Damor
- Modality
- Small Molecules
- Administration
- Topical, Vaginal
01
Overview
Triticum vulgare aqueous extract + polyhexanide is a topical combination product, often classified as a medical device, used for the management of acute and chronic skin lesions. The Triticum vulgare extract, specifically the Rigenase fraction obtained from germinated wheat plants, promotes wound healing by stimulating fibroblast activity, chemotaxis, and granulation tissue formation. It also exerts anti-inflammatory effects by reducing mediators such as IL-6, TNFα, and prostaglandin E2. Polyhexanide (PHMB) serves as a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes, preventing infection in the wound bed. This combination is particularly utilized in the treatment of diabetic foot ulcers, venous leg ulcers, burns, and gynecological conditions such as vulvovaginitis and cervical ectropion.
- Brand names
- Fitostimoline Plus
- Other names
- Rigenase + polyhexanideTriticum vulgare extract + PHMBTriticum vulgare extract + polyhexamethylene biguanide
02
Targets
IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))PGN (Peptidoglycan)Neuraminidase
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