trivalent inactivated subunit influenza vaccine, non-adjuvanted

A **trivalent inactivated subunit influenza vaccine, non-adjuvanted** is a seasonal influenza vaccine that contains inactivated split or subunit viral proteins from three influenza strains—two influenza A (H1N1 and H3N2) and one influenza B[1][4]. The “subunit” formulation is highly purified to primarily include surface antigens, such as hemagglutinin (HA), with minimal internal viral components. The vaccine is **non-adjuvanted**, meaning no immune response-enhancing additive is included. It induces immunity by stimulating antibody production against the HA antigen of the included viral strains, providing protection primarily by targeting protective epitopes on hemagglutinin[1][2]. Non-adjuvanted subunit influenza vaccines are well tolerated with a long record of safe use; they tend to have reduced reactogenicity compared to whole-virus formulations but may be less immunogenic in unprimed populations (e.g., young children)[2]. These vaccines are typically produced using embryonated chicken eggs, and the final product is standardized to contain 15 μg of HA per strain (total 45 μg HA per 0.5 mL adult dose)[1]. Primary indication is **prevention of seasonal influenza** in children and adults.

Other names

trivalent inactivated influenza vaccine, non-adjuvantedinactivated trivalent influenza vaccine, subunit, non-adjuvantedTIV subunit, non-adjuvantedtrivalent influenza vaccine, subunit, non-adjuvanted