Drug intelligence / Profile preview

tryptophan + theanine + adenosine 5'-monophosphate

Development stage
Unknown
Lead developer
Bio-Design
Modality
Small Molecules
Administration
Oral, Sublingual
01

Overview

tryptophan + theanine + adenosine 5'-monophosphate is a multi-ingredient dietary supplement formulation designed to promote relaxation, reduce anxiety, and support healthy sleep architecture. The combination leverages the synergistic effects of three key molecules: L-tryptophan, an essential amino acid that serves as the primary metabolic precursor for serotonin and melatonin synthesis; L-theanine, an amino acid found in tea leaves that promotes relaxation by antagonizing glutamate receptors and increasing GABA levels without causing drowsiness; and adenosine 5'-monophosphate (AMP), a nucleotide that supports cellular energy and acts as a precursor to adenosine, a key endogenous sleep-promoting signal. This formulation is primarily marketed as a nutraceutical for individuals experiencing stress-related sleep disturbances or mild anxiety.

Brand names
TranquilTranquil-SL
Other names
L-tryptophan + L-theanine + AMPL-tryptophan + L-theanine + adenosine 5'-monophosphate
02

Targets

HTR3A (5-hydroxytryptamine receptor 3A)ADORA1 (Adenosine receptor A1 subtype)MTNR1A (MT1)iGluR (Ionotropic receptor 76b (Ir76b))

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