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turmeric + black cumin seed
- Development stage
- Unknown
- Lead developer
- LifeExtension
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Turmeric + black cumin seed** is a combination product or polyherbal supplement containing extracts or oils from turmeric (*Curcuma longa*) rhizomes and black cumin (*Nigella sativa*) seeds. Both ingredients have been widely studied for anti-inflammatory, antioxidant, immune modulating, and metabolic health benefits. This combination is formulated to maximize efficacy, with some commercial supplements using proprietary forms for enhanced absorption, such as curcumin elite and concentrated black cumin seed oil. The mechanism of action involves synergistic effects: curcumin from turmeric inhibits NF-κB activation and scavenges free radicals, while thymoquinone from black cumin seed and other essential oil constituents act as anti-inflammatory, antioxidant, and cytotoxic agents via protein denaturation inhibition, free radical scavenging, and modulating targets related to ROS and cancer cell proliferation (such as NOX2, NF-κB, and mdm2)[1][2][3].
- Brand names
- Black Cumin Seed Oil with Curcumin Elite
- Other names
- turmeric and black cuminturmeric-black seedturmeric + Nigella sativaCurcuma longa + Nigella sativa
02
Targets
NOX2 (NADPH oxidase 2)MDM2 (Mouse double minute 2 homolog)
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