Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Twinrix-Merck Sharp & Dohme LLC-tetanus-diphtheria-hepatitis A-hepatitis B-cholera
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Oral
01
Overview
This entry refers to a specific combination vaccine regimen evaluated by Merck Sharp & Dohme LLC in a Phase I observational study (NCT01832831). The regimen consists of three distinct vaccine products: Twinrix (a combined Hepatitis A and Hepatitis B vaccine), a Tetanus and Diphtheria (Td) booster, and Dukoral (an oral cholera vaccine). The study aimed to develop biomarker-based prediction rules for vaccine hyporesponse in healthy elderly individuals by measuring antibody titers across these diverse antigenic challenges. Twinrix provides active immunization against Hepatitis A and B; Td provides a booster against Clostridium tetani and Corynebacterium diphtheriae; and Dukoral provides protection against Vibrio cholerae and heat-labile enterotoxin-producing E. coli.
- Brand names
- TwinrixDukoral
- Other names
- Td + Twinrix + Dukoral
02
Targets
Hepatitis A virus capsid proteinHBsAg (Hepatitis B surface antigen)
Beyond the preview
Go deeper on Twinrix-Merck Sharp & Dohme LLC-tetanus-diphtheria-hepatitis A-hepatitis B-cholera.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Twinrix-Merck Sharp & Dohme LLC-tetanus-diphtheria-hepatitis A-hepatitis B-cholera.