tyrothricin + benzalkonium chloride + benzocaine

This is a **fixed-dose combination** drug containing **tyrothricin** (an antimicrobial polypeptide mixture), **benzalkonium chloride** (a quaternary ammonium antiseptic with mild anesthetic and antiviral effects), and **benzocaine** (a local anesthetic). The combination is used primarily as a **lozenge** for symptomatic and local treatment of acute pharyngitis and sore throat. Tyrothricin provides broad-spectrum antibacterial and weak antifungal activity by disrupting microbial membranes. Benzalkonium chloride acts as a disinfectant and antiseptic with additional mild antiviral properties, while benzocaine provides rapid local analgesia by blocking sodium channels in neuronal membranes, inhibiting the initiation and conduction of nerve impulses. The triple combination offers **synergistic analgesic and antimicrobial effects**, leading to rapid symptom relief and improved remission rates in sore throat and pharyngitis compared to placebo. It is marketed chiefly under the brand Dorithricin.

Brand names

Dorithricin

Other names

tyrothricin, benzalkonium chloride, benzocaine drug combination