udenafil + dapoxetine

Udenafil + dapoxetine is a fixed-dose combination of two small molecule drugs used in the management of male sexual dysfunction. Udenafil is a phosphodiesterase type 5 (PDE5) inhibitor indicated for erectile dysfunction; it works by inhibiting PDE5, thereby increasing cyclic GMP levels and promoting smooth muscle relaxation and increased blood flow to the corpus cavernosum during sexual stimulation[6][2][3]. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) developed specifically for the treatment of premature ejaculation; it acts by inhibiting neuronal reuptake of serotonin, enhancing serotonergic activity in central ejaculatory pathways, and delaying ejaculation[1][4][5]. The combination targets both erectile dysfunction and premature ejaculation in men. Clinical studies indicate that co-administration does not result in clinically significant pharmacokinetic interactions, and the regimen is generally well tolerated[2][3].