ulipristal acetate + ethinylestradiol + levonorgestrel

This is a **combination of three active pharmaceutical ingredients**: ulipristal acetate, ethinylestradiol, and levonorgestrel. - **Ulipristal acetate** is a **selective progesterone receptor modulator** with both antagonist and partial agonist activity, mainly used as an emergency contraceptive. Its primary mechanism is to inhibit or delay ovulation by preventing follicular rupture, with possible additional effects on endometrial maturation[1][4]. - **Ethinylestradiol** is a synthetic **estrogen** mainly used in combined oral contraceptives. It acts by inhibiting ovulation via suppression of gonadotropin secretion and by altering the endometrium and cervical mucus to prevent implantation and sperm penetration[4]. - **Levonorgestrel** is a **synthetic progestin**, also widely used for emergency contraception and in combination oral contraceptives. It inhibits or delays ovulation and causes endometrial and cervical mucus changes adverse to implantation and fertilization[4][5]. There is no evidence of this precise three-drug combination as a marketed pharmaceutical product, and combining ulipristal acetate with estrogens or progestins may interfere with the individual drug efficacy, particularly reducing ulipristal's contraceptive effect[2][3]. **Warnings:** Direct combination of ulipristal acetate with ethinylestradiol and levonorgestrel is not a recommended or standard therapeutic approach as simultaneous or near-concurrent usage can reduce the emergency contraceptive efficacy of ulipristal acetate.

Brand names

ellaOneMicrogynon

Other names

UPA + EE/LNGulipristal acetate + ethinylestradiol/levonorgestrel