Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
umbilical cord-derived mesenchymal stem cells (Shandong University)
- Development stage
- Unknown
- Lead developer
- Shandong University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Umbilical cord-derived mesenchymal stem cells (uMSCs) are an investigational cell therapy developed by researchers at the Second Hospital of Shandong University for the treatment of ankylosing spondylitis (AS). These cells are derived from human umbilical cord or placenta and administered via intravenous infusion. The therapy functions through potent immunomodulatory mechanisms, including the inhibition of B cell differentiation and T cell activation, the induction of regulatory T cells (Tregs), and the suppression of Th17 cell generation and interleukin-17 (IL-17) secretion. A Phase II clinical trial (NCT01420432) evaluated the safety and efficacy of these uMSCs at a dose of 1.0E+6 MSC/kg, often in combination with disease-modifying antirheumatic drugs (DMARDs), demonstrating a favorable safety profile and clinical improvement in disease activity and symptoms.
- Other names
- uMSCshuman umbilical cord-derived MSCsumbilical cord/placenta-derived mesenchymal stem cells
Beyond the preview
Go deeper on umbilical cord-derived mesenchymal stem cells (Shandong University).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on umbilical cord-derived mesenchymal stem cells (Shandong University).