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Umbilical cord mesenchymal stem cell-derived exosomes (Zhongshan Ophthalmic Center)
- Development stage
- Unknown
- Lead developer
- Zhongshan Ophthalmic Center
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Ophthalmic, Topical
01
Overview
This investigational biologic therapy consists of exosomes derived from human umbilical cord mesenchymal stem cells (UC-MSCs), developed by the Zhongshan Ophthalmic Center at Sun Yat-sen University. It is specifically being developed as a cell-free therapeutic approach for treating dry eye syndrome in patients with chronic graft-versus-host disease (cGVHD). Administered as topical eye drops, these nanosized extracellular vesicles contain a cargo of bioactive molecules, including proteins and microRNAs such as miR-204. The therapy exerts immunomodulatory and anti-inflammatory effects by reprogramming proinflammatory M1 macrophages into immunosuppressive M2 macrophages. This transition is achieved through the miR-204-mediated targeting and inhibition of the IL-6/IL-6R/Stat3 signaling pathway, which helps alleviate ocular surface inflammation and improve clinical symptoms of dry eye.
- Other names
- Umbilical Mesenchymal Stem Cells derived Exosomeshuman umbilical cord mesenchymal stem cell-derived exosomes
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)IL-6R (Interleukin-6 receptor subunit alpha)
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