urea + crosslinked-hyaluronate

Urea + crosslinked-hyaluronate is a combination product consisting of the small molecule urea and a form of hyaluronic acid (hyaluronate) that has been chemically cross-linked using urea as the crosslinking agent. This formulation leverages the synergistic effects of both components for enhanced therapeutic benefit. Urea acts as a keratolytic and humectant, promoting hydration and softening of tissues, while crosslinked hyaluronate provides viscoelasticity, tissue adhesion, and prolonged residence time at application sites due to its gel-like structure. The combination has demonstrated anti-inflammatory properties, improved wound healing capacity, and potential antioxidant effects in preclinical studies. It is being explored primarily for topical or local administration in conditions involving inflammation or tissue damage—such as skin diseases (cutaneous disorders), rectal mucosal lesions[1], and inflammatory lung diseases[2][5]. Crosslinking with urea modifies the physical properties of hyaluronan gels to enhance their stability and biological activity[5][6].

Other names

urea + crosslinked hyaluronic acidurea-crosslinked hyaluronateurea-crosslinked hyaluronic acid