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urea + hydrocortisone (GSK)
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Topical
01
Overview
Urea + hydrocortisone is a fixed-dose topical combination of urea, an emollient and keratolytic, and hydrocortisone, a synthetic glucocorticoid steroid. Urea hydrates, softens, and removes scaly or thickened skin, while hydrocortisone acts as an anti-inflammatory, anti-pruritic, and immunosuppressant by binding glucocorticoid receptors and regulating transcription of anti-inflammatory proteins. The combination is used to treat symptoms of skin conditions including itching, redness, dryness, scaling, and inflammation, especially in corticosteroid-responsive dermatoses such as eczema, dermatitis, and allergic reactions[4][5][6].
- Brand names
- Uremol HCTi-U-Lac HU-Cort
- Other names
- hydrocortisone and urea topical
02
Targets
GR (Glucocorticoid receptor)
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