urolithin a + fisetin

Urolithin A + fisetin is a combination of two natural compounds, urolithin A and fisetin, designed to leverage their complementary biological activities. Urolithin A is a gut microbiota-derived metabolite of ellagitannins (found in foods like pomegranate and walnuts) with demonstrated anti-inflammatory, antioxidant, anti-proliferative, and mitochondrial autophagy (mitophagy) inducing properties. It has been studied for its roles in regulating estrogen secretion, inhibiting adipogenesis via suppression of PPARγ and C/EBP gene expression, promoting osteogenic differentiation of mesenchymal stem cells, as well as potential benefits in obesity management and neurodegenerative diseases[2][3][4][5][7]. Fisetin is a flavonoid found in various fruits and vegetables known for its senolytic activity—selectively clearing senescent cells—and also exhibits antioxidant and anti-inflammatory effects. The combination aims to synergistically target circadian rhythm regulation (via urolithin A’s mitochondrial effects) alongside the clearance of aging/senescent cells (via fisetin), potentially offering new therapeutic options for complex conditions such as menopausal sleep disorders[1]. Both components are under investigation primarily as dietary supplements or research compounds rather than approved pharmaceuticals.

Other names

尿石素A + 非瑟酮