Drug intelligence / Profile preview

uronext + fosfomycin trometamol

Development stage
Unknown
Lead developer
Zambon Group
Modality
Small Molecules
Administration
Oral
01

Overview

This drug is a combination of **uronext**, a branded product (details on its separate composition not directly available in provided search results), and **fosfomycin trometamol** (also referred to as fosfomycin tromethamine), which is the oral salt form of the antibiotic **fosfomycin**. Fosfomycin trometamol is a synthetic, broad-spectrum, bactericidal antibiotic administered orally, principally for the treatment of acute uncomplicated lower urinary tract infections in women. The mechanism of action is inhibition of bacterial cell wall synthesis via irreversible blocking of the enzyme enolpyruvyl transferase, interfering with peptidoglycan biosynthesis. The fosfomycin component is highly active against a wide spectrum of urinary tract pathogens, including *Escherichia coli* and *Enterococcus faecalis*. The combination product presumably aims to leverage these antibacterial properties, but no data on the additional mechanisms or indications for uronext is found in the search results. Fosfomycin trometamol is well tolerated, with mainly mild, transient gastrointestinal side effects[1][2][4][5][7].

Other names
uronext + fosfomycin tromethamineuronext + fosfomycin trometamol
02

Targets

MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase)

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