ursodeoxycholic acid + silymarin

**Ursodeoxycholic acid + silymarin** is a fixed-dose combination of two distinct hepatoprotective agents used for the management of liver diseases. Ursodeoxycholic acid, a hydrophilic bile acid, acts primarily by replacing cytotoxic bile acids, improving bile flow, and reducing cholesterol saturation, thereby aiding in the management of cholestatic liver disorders and certain gallstone conditions[2][5][8]. Silymarin, an extract from *Silybum marianum* (milk thistle), is a potent antioxidant and free radical scavenger that protects hepatocytes from oxidative stress and membrane injury, modulates inflammation, and inhibits fibrogenesis, thus supporting hepatic repair[3][6][9]. The combination is used in various acute and chronic liver disorders, including viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), cirrhosis, and primary biliary cholangitis[1][7][4][10].

Brand names

UdibonActimarinUrsokem PlusUlyses PlusUrdohep SLUdimarinUdiplusUrsodox PlusUdimarin ForteGemiuro Plus

Other names

silymarin + ursodeoxycholic acidsilymarin-ursodeoxycholic acidUDCA + silymarin