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USL311 + lomustine
- Development stage
- Discontinued
- Lead developer
- Proximagen
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
USL311 + lomustine is a combination regimen consisting of USL311, a small molecule antagonist of the CXCR4 receptor, and lomustine, a cytotoxic nitrosourea alkylating agent. USL311 targets the CXCR4 receptor, inhibiting migration, self-renewal, and survival of cancer stem cells, potentially sensitizing them to chemotherapy via inhibition of autophagy. Lomustine, primarily used as an oral chemotherapeutic agent in brain tumors, functions through alkylation of DNA, leading to cytotoxicity. This combination has been evaluated in Phase 1/2 clinical trials for advanced solid tumors and relapsed/recurrent glioblastoma multiforme (GBM), with USL311 hypothesized to enhance the efficacy of lomustine by overcoming tumor resistance linked to cancer stem cells[1][2][3][5].
- Other names
- CCNUUSL311 + CCNU
02
Targets
NeuraminidaseCXCR4 (C-X-C motif chemokine receptor 4)DNA
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