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vagitories + probiotic

Development stage
Preclinical
Lead developer
Center for Applied Microbiome Research
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Vaginal (suppository)
01

Overview

A combination product consisting of a vaginal suppository (vagitory) containing probiotics, typically strains of Lactobacillus such as Lactobacillus acidophilus or Lactobacillus rhamnosus. These products are designed to be inserted into the vagina to help restore or maintain a healthy vaginal microbiome by increasing the population of beneficial bacteria and reducing overgrowth of pathogenic organisms. The primary indications include prevention and adjunctive treatment of bacterial vaginosis, yeast infections, and genitourinary syndrome of menopause. The mechanism involves competitive inhibition against pathogenic microbes and restoration of normal acidic pH via lactic acid production by lactobacilli[1][2][3][7]. Efficacy evidence is mixed; some studies suggest benefit in certain conditions like bacterial vaginosis, but conclusive clinical data are lacking[3][9]. Probiotic vaginal suppositories are generally considered safe for healthy individuals but may cause mild gastrointestinal symptoms or rare allergic reactions; immunocompromised patients should use caution[5][6].

Other names
vaginal suppository with probioticvaginal probiotic suppository

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