Drug intelligence / Profile preview

valsartan + metformin

Development stage
Phase 4
Lead developer
Myopharm
Modality
Small Molecules
Administration
Oral
01

Overview

Valsartan + metformin is a combination drug therapy that pairs an angiotensin receptor blocker (valsartan) with a biguanide antidiabetic medication (metformin). This combination is being studied for use in patients with both type 2 diabetes and hypertension. Valsartan works by blocking angiotensin II receptors, which helps lower blood pressure, while metformin improves insulin sensitivity and reduces glucose production in the liver. Studies suggest this combination may have synergistic effects, with valsartan potentially enhancing the hypoglycemic effects of metformin.

02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)AGTR1 (Angiotensin II Type-1 receptor)ND1 (Mitochondrial electron transport chain complex I)

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