Drug intelligence / Profile preview

varenicline + nicotine patch

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Transdermal
01

Overview

Varenicline plus nicotine patch is a combination therapy for smoking cessation that pairs varenicline (a partial agonist of nicotinic acetylcholine receptors) with nicotine replacement therapy in patch form. The combination aims to enhance smoking cessation effectiveness by potentially providing better receptor saturation and craving control. Varenicline works by binding to α4β2 nicotinic acetylcholine receptors, reducing both the rewarding effects of nicotine and withdrawal symptoms, while the nicotine patch provides a steady level of nicotine throughout the day to help ease withdrawal symptoms.

Other names
varenicline and nicotine patchvarenicline and nicotine replacement therapy
02

Targets

α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)CHRNA7 (α7 nicotinic receptor)

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