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varenicline + prazosin
- Development stage
- Unknown
- Lead developer
- Yale University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Varenicline + prazosin is a combination therapy being investigated by Yale University for the treatment of heavy-drinking cigarette smokers. Varenicline is an FDA-approved smoking cessation aid that acts as a partial agonist at the alpha-4 beta-2 nicotinic acetylcholine receptor, reducing nicotine cravings and withdrawal symptoms. However, varenicline is frequently associated with sleep disturbances, including vivid dreams and insomnia. Prazosin, an alpha-1 adrenergic receptor antagonist traditionally used for hypertension and PTSD-related nightmares, is added to the regimen to mitigate these sleep-related side effects. Beyond improving sleep quality, the combination is being studied for its potential synergistic effects in reducing both nicotine dependence and heavy alcohol consumption in comorbid populations.
- Other names
- varenicline and prazosin
02
Targets
α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)α6β2 nAChR (α6β2 nicotinic receptor)ADRA1A (α1A)α3β2 nAChR (α3β2 nicotinic receptor)CHRNA7 (α7 nicotinic receptor)
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