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varicella vaccine + hepatitis A vaccine (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo)
- Development stage
- Unknown
- Lead developer
- University of Sao Paulo General Hospital
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous
01
Overview
This refers to a clinical research protocol conducted by the University of São Paulo General Hospital (NCT00926419) evaluating the immunogenicity and safety of fractional doses of varicella and hepatitis A vaccines. The study specifically utilizes a disposable needle-free syringe jet injector (DSJI) for intradermal delivery of reduced doses (dose-sparing) compared to standard subcutaneous or intramuscular administration via conventional syringe. The varicella component is a live attenuated Oka strain virus, while the hepatitis A component is an inactivated virus vaccine. The primary objective is to determine if fractional doses delivered via DSJI can elicit a comparable immune response to full doses, potentially increasing vaccine affordability and accessibility in public health programs.
- Other names
- Varicella and Hepatitis A Vaccines via Needle-Free Injectorfractional dose varicella vaccinefractional dose hepatitis A vaccine
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