Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
vatalanib + everolimus
- Development stage
- Phase 1
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Combination of the small-molecule VEGFR tyrosine kinase inhibitor vatalanib with the mTOR inhibitor everolimus for advanced solid tumors, including renal cell carcinoma. Vatalanib inhibits vascular endothelial growth factor receptors (VEGFR-1/2/3) and related angiogenic kinases, suppressing tumor angiogenesis; everolimus inhibits mTOR complex 1, reducing tumor cell growth, proliferation, and metabolism. Phase I/Ib studies established maximum tolerated doses and showed manageable toxicity with signals of antitumor activity across tumor types and in metastatic RCC dose-expansion cohorts. Investigated in trials such as NCT00655655 and other early-phase studies.
- Other names
- vatalanib plus everolimusvatalanib and everolimusvatalanib PTK787 ZK222584 plus everolimus RAD001
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)FKBP1APDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)Mechanistic target of rapamycin complex 1
Beyond the preview
Go deeper on vatalanib + everolimus.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on vatalanib + everolimus.