Drug intelligence / Profile preview

Vaxigrip Tetra + Arexvy

Development stage
Unknown
Lead developer
Wroclaw Medical University
Modality
Whole Inactivated Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration
Intramuscular
01

Overview

Vaxigrip Tetra + Arexvy is a coordinated vaccination regimen being investigated by Wroclaw Medical University for patients with chronic heart failure. The intervention consists of the simultaneous administration of Vaxigrip Tetra, a quadrivalent inactivated influenza vaccine manufactured by Sanofi, and Arexvy, a recombinant respiratory syncytial virus (RSV) vaccine manufactured by GSK. Vaxigrip Tetra contains hemagglutinin antigens from four influenza strains (A/H1N1, A/H3N2, and two B lineages), while Arexvy utilizes a recombinant RSV pre-fusion F protein antigen combined with the AS01E adjuvant system. The primary objective of this coordinated approach is to improve the clinical prognosis of high-risk heart failure patients by reducing the incidence of respiratory infections and associated cardiovascular complications during the infection season.

Brand names
Vaxigrip TetraArexvy
Other names
Coordinated Vaccination against RSV and influenzainfluenza vaccine-Wroclaw Medical University-RSV infection-influenza
02

Targets

RSV F (Respiratory syncytial virus fusion protein)HA (Hemagglutinin)

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