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vebecotutamab + lenvatinib
- Development stage
- Phase 2
- Lead developer
- MacroGenics
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
vebecotutamab + lenvatinib is a combination therapy being investigated for the treatment of salivary gland carcinoma. Vebecotutamab (MGD019) is a bispecific DART (Dual-Affinity Re-Targeting) molecule designed to simultaneously target and block the immune checkpoint receptors PD-1 and CTLA-4, thereby enhancing T-cell activation and anti-tumor immune responses. Lenvatinib is an oral multi-receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR1-3), fibroblast growth factor receptors (FGFR1-4), platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET. By combining dual checkpoint blockade with anti-angiogenic and anti-proliferative kinase inhibition, this regimen aims to overcome tumor-induced immunosuppression and inhibit tumor growth and vascularization. It is currently being evaluated in a Phase 2 umbrella trial sponsored by Peking Union Medical College for patients with locally advanced, recurrent, or metastatic salivary gland carcinoma.
- Other names
- MGD019 + lenvatinibvebecotutamab ± lenvatinib
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDCD1 (Programmed cell death protein 1 receptor)PDGFRA (Platelet-derived growth factor receptor alpha)RET (Rearranged during transfection receptor tyrosine kinase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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