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VELGRAFT (1abdcc)
- Development stage
- Unknown
- Lead developer
- Ayu
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Topical
01
Overview
VELGRAFT is a living cellular construct developed by Ayu, Inc. for the management of chronic diabetic foot ulcers (DFU). It is a combination product composed of allogeneic human bone marrow-derived mesenchymal stem cells (MSCs) and MSCs differentiated into adipocytes, seeded onto a porous chitosan-gelatin matrix. The product is applied topically to ulcers that have already attained granulation tissue. The MSCs used in VELGRAFT are derived from FDA-registered bone marrow sources and are tested for HLA-2 markers to minimize the risk of immune rejection. Additionally, the cells are cultured in xenogeneic-free medium to reduce sensitivity to animal products. VELGRAFT functions as a regenerative scaffold, providing both living cells and a structural matrix to facilitate the healing of complex wounds.
- Brand names
- VELGRAFT
- Other names
- allogeneic human bone marrow-derived mesenchymal stem cells + mesenchymal stem cell-derived adipocytesliving cellular construct
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