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vibostolimab + pembrolizumab + capecitabine + oxaliplatin
- Development stage
- Phase 2
- Lead developer
- Merck
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous (vibostolimab, Pembrolizumab, Oxaliplatin), Oral (capecitabine)
01
Overview
This is an investigational **combination regimen** of four drugs: **vibostolimab**, an anti-TIGIT monoclonal antibody that blocks TIGIT-mediated immunosuppression and activates T cells; **pembrolizumab**, an anti-PD-1 monoclonal antibody checkpoint inhibitor that boosts T cell anti-tumor activity; **capecitabine**, a small molecule oral prodrug of 5-fluorouracil (5-FU) used as a chemotherapy agent; and **oxaliplatin**, a platinum-based chemotherapeutic agent that crosslinks DNA and induces tumor cell death. This combination is being studied in clinical trials for the treatment of solid tumors, with ongoing evaluation primarily in non-small cell lung cancer and potentially other tumor types[1][3][7].
- Brand names
- KEYTRUDA (pembrolizumab)Xeloda (capecitabine)Eloxatin (oxaliplatin)
- Other names
- vibostolimab + pembrolizumab + capecitabine + oxaliplatin
02
Targets
DNAPDCD1 (Programmed cell death protein 1 receptor)TIGIT (T cell immunoreceptor with Ig and ITIM domains)TS (Thymidylate synthase)
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