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vincristine + dexamethasone
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Vincristine + dexamethasone is a combination regimen commonly used in the treatment of hematologic malignancies, particularly acute lymphoblastic leukemia (ALL) in children and as part of induction regimens for multiple myeloma. Vincristine is a vinca alkaloid antineoplastic agent that binds to tubulin, inhibiting microtubule formation and arresting cell division at metaphase, leading to apoptosis. Dexamethasone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties; it induces apoptosis in certain cancer cells and reduces inflammation. The combination exploits the cytotoxic effects of vincristine on rapidly dividing cells with the lympholytic and anti-inflammatory actions of dexamethasone[1][2][5].
- Other names
- vincristine sulfatehexadecadrol
02
Targets
GR (Glucocorticoid receptor)TUBB4A (β-tubulin 4A)
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