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vincristine + mercaptopurine + cyclophosphamide + cytarabine + L-asparaginase + intrathecal methotrexate
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Small Molecules
- Administration
- Intravenous, Oral, Intramuscular, Subcutaneous, Intrathecal
01
Overview
This is a combination chemotherapy regimen used primarily in the treatment of acute lymphoblastic leukemia (ALL). The regimen includes multiple agents that work through different mechanisms to target cancer cells. Intrathecal methotrexate is specifically administered directly into the cerebrospinal fluid to treat or prevent cancer in the central nervous system, while the other components are typically administered systemically. This multi-agent approach is designed to maximize efficacy while managing toxicity.
02
Targets
DHFR (Dihydrofolate reductase)DNAHPRT1 (Hypoxanthine-guanine phosphoribosyltransferase)PPAT (Amidophosphoribosyltransferase)
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