vitamin B complex + alpha-lipoic acid + SSRI

This combination therapy refers to the standard medical treatment arm used in clinical research conducted by Assiut University for the management of diabetic peripheral neuropathy (DPN). The regimen consists of a vitamin B complex, alpha-lipoic acid, and a selective serotonin reuptake inhibitor (SSRI). Vitamin B complex (typically including B1, B6, and B12) is utilized to support neuronal metabolic processes and facilitate nerve repair. Alpha-lipoic acid acts as a potent antioxidant that mitigates oxidative stress-induced nerve damage and improves endoneurial blood flow. SSRIs are included to modulate central pain signaling pathways and address comorbid depressive symptoms often associated with chronic neuropathic pain. This multi-modal approach targets both the underlying metabolic pathophysiology and the symptomatic manifestations of peripheral nerve dysfunction in diabetic patients.

Other names

medical-Assiut University-diabetic peripheral neuropathymedical treatmentstandard medical therapy for DPN