Drug intelligence / Profile preview

vitamin c + caffeine + turmeric

Development stage
Preclinical
Lead developer
Advanced Clinicals
Modality
Small Molecules
Administration
Topical
01

Overview

This topical stick formulation is a combination of Vitamin C, caffeine, and turmeric designed to address signs of periocular aging, including hyperpigmentation, puffiness, and wrinkles. Vitamin C (ascorbic acid) serves as a potent antioxidant and skin-brightening agent by inhibiting tyrosinase, the enzyme responsible for melanin synthesis. Caffeine acts as a vasoconstrictor to reduce periorbital puffiness and improve microcirculation, which helps alleviate the appearance of dark circles. Turmeric (curcuminoids) provides anti-inflammatory and antioxidant benefits, further aiding in the reduction of oxidative stress and improving skin luminosity. Clinical data presented at the AAD 2026 meeting demonstrated that the formulation is chemically stable and significantly improves periorbital hyperpigmentation, wrinkles, and luminosity with high tolerability and no observed adverse effects.

Other names
Vitamin C, Caffeine, and Turmeric Stick
02

Targets

ADORA2A (Adenosine A₂A Receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TYR (Tyrosinase)ADOR (Adenosine receptors)

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