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Vitamin E + evening primrose oil is a combination dietary supplement containing two active ingredients: vitamin E (a fat-soluble antioxidant) and evening primrose oil (EPO), which is rich in gamma-linolenic acid (GLA), an omega-6 essential fatty acid. This combination is primarily marketed for its potential benefits in managing cyclical mastalgia (cyclic breast pain), premenstrual syndrome (PMS), menopausal symptoms, skin health, and as an antioxidant. The mechanism of action involves the anti-inflammatory effects of GLA from EPO—modulating prostaglandin synthesis—and the antioxidant properties of vitamin E that protect cells from oxidative damage. Clinical studies suggest that the combination may provide superior relief for cyclical mastalgia compared to either agent alone or placebo[2][7]. It is available as a dietary supplement in softgel or capsule form.
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