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Drug intelligence / Profile preview
Weichang'an
- Development stage
- Phase 4
- Lead developer
- State Administration of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Weichang'an is a traditional Chinese medicine (TCM) herbal formula used primarily for gastrointestinal disorders. It is most commonly indicated for diarrhoea-predominant irritable bowel syndrome (IBS-D), where it has been shown to alleviate symptoms by modulating the cyclic adenosine monophosphate (cAMP) signaling pathway[1]. The formula also demonstrates anti-inflammatory, antibacterial, and antiviral properties[3], and has been studied for its effects on ulcerative colitis and constipation[4][6]. In oncology research, Weichang'an has shown potential in inhibiting tumor growth in gastric and colorectal cancer models by inducing mitochondrial apoptosis in cancer cells through modulation of proteins such as Bcl-2 family members and caspases[2][5]. Its mechanisms include regulation of cell proliferation, apoptosis induction via mitochondrial pathways, inhibition of STAT3 signaling in tumors, and improvement of gastrointestinal motility.
- Brand names
- Weichang'an
- Other names
- WeiChang'An PillWeichang'an formulaWei Chang An pill
02
Targets
BCL-2 (BCL-2 family)CASP (Caspase family)STAT3 (Signal Transducer and Activator of Transcription 3)
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