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withalongolide o 4,7-diacetate
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
Withalongolide O 4,7-diacetate is a semisynthetic withanolide derivative synthesized from withalongolide O, a natural product isolated from Physalis longifolia. It is chemically identified as the 4,7-diacetate derivative of 27-deoxy-7β-hydroxy-withaferin A. This small molecule has demonstrated potent antiproliferative and cytotoxic activity in vitro against various cancer cell lines, including human head and neck squamous cell carcinoma (JMAR and MDA-1986) and melanoma (B16F10 and SKMEL-28), with IC50 values reported as low as 0.067 nM. As a member of the withanolide class, it is primarily utilized in research to explore structure-activity relationships for the development of novel antineoplastic agents.
- Other names
- 4,7-diacetate derivative of withalongolide O
02
Targets
BIRC5 (Survivin)mTOR (Mammalian target of rapamycin kinase)HSP90 (Heat shock protein 90 chaperone complex)AKT (RAC-alpha serine/threonine-protein kinase)RPS6KB1 (Ribosomal protein S6 kinase beta-1)MYCN (N-myc proto-oncogene protein)CCND1 (Cyclin D1)
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