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Xin'an Guben Peiyuan Bushen Rougan Fang
- Development stage
- Unknown
- Lead developer
- First Affiliated Hospital of Anhui University of Chinese Medicine
- Administration
- Oral
01
Overview
Xin'an Guben Peiyuan Bushen Rougan Fang is a Traditional Chinese Medicine (TCM) herbal formula rooted in the Xin'an medical tradition, specifically designed to treat chronic liver diseases. The formula's name reflects its therapeutic strategy: "Guben Peiyuan" (strengthening the foundation and cultivating vital energy) and "Bushen Rougan" (tonifying the kidney and nourishing the liver). It is primarily developed and researched by institutions such as the Anhui University of Chinese Medicine for the treatment of chronic hepatitis B, liver fibrosis, and cirrhosis. The pharmacological mechanism involves the inhibition of the TGF-beta1/Smad signaling pathway, which prevents the activation of hepatic stellate cells (HSCs) and their subsequent transformation into myofibroblasts, thereby reducing the synthesis of extracellular matrix components like collagen. Additionally, the formula exhibits immunomodulatory effects by balancing Th1/Th2 cytokines and reducing pro-inflammatory markers such as IL-6 and TNF-alpha, which helps mitigate chronic hepatic inflammation and prevents progression to hepatocellular carcinoma.
- Other names
- 新安固本培元补肾柔肝方Xin'an Guben Peiyuan Bushen Rougan Formula
02
Targets
TGFB1 (Transforming growth factor Beta-1 proprotein)
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