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xylometazoline + dexamethasone
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Intranasal, Topical
01
Overview
Xylometazoline + dexamethasone is a fixed-dose combination nasal preparation used primarily for the symptomatic relief of nasal congestion and inflammation associated with allergic rhinitis, sinusitis, or upper respiratory tract infections. Xylometazoline is an imidazoline derivative and direct-acting alpha-adrenergic agonist that causes vasoconstriction of the nasal mucosa by stimulating alpha-adrenoceptors, leading to reduced swelling and improved airflow[2][7]. Dexamethasone is a potent synthetic corticosteroid that binds to glucocorticoid receptors to inhibit pro-inflammatory signals and suppress immune responses[3][5]. The combination leverages the rapid decongestant effect of xylometazoline with the anti-inflammatory action of dexamethasone for enhanced symptomatic relief in conditions where both congestion and inflammation are present.
- Brand names
- Otrivin-DXyloDexa
- Other names
- xylomethazoline + dexamethasone
02
Targets
ADRA1A (α1A)GR (Glucocorticoid receptor)ADRA2A (α2A)
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