Drug intelligence / Profile preview

Yangxinshi (Shanghai Pharmaceuticals Holding Co Ltd)

Development stage
Unknown
Lead developer
Shanghai Pharmaceuticals Group Qingdao Growful Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Yangxinshi is a Traditional Chinese Medicine (TCM) formulation, commonly available as Yangxinshi tablets (Yangxinshi Pian), used for the treatment of various cardiovascular conditions. It is composed of a complex mixture of herbal extracts, including *Panax ginseng*, *Astragalus membranaceus*, *Salvia miltiorrhiza*, and *Crataegus pinnatifida*. The drug is primarily indicated for chronic coronary syndrome (CCS), angina pectoris, and chronic heart failure. Its therapeutic effects are attributed to its ability to improve myocardial energy metabolism, enhance coronary blood flow, and provide anti-inflammatory and antioxidant protection to the cardiovascular system. In clinical practice, it is often used as an adjunctive therapy alongside standard Western medications. A significant Phase 4 clinical trial (NCT05484505) led by Shandong First Medical University has investigated its impact on exercise capacity in patients with CCS.

Brand names
Yangxinshi
Other names
Yangxinshi tabletYangxinshi Pian
02

Targets

CBLB (CBL-B)TGFβ/SMAD2 (Transforming growth factor beta/SMAD2 signaling pathway)

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