Drug intelligence / Profile preview

yinqiaosan + maxingganshitang

Development stage
Phase 4
Lead developer
China Academy of Chinese Medical Sciences
Modality
Small Molecules
Administration
Oral
01

Overview

Yinqiaosan + maxingganshitang is a combination of two foundational Traditional Chinese Medicine (TCM) formulas used for the treatment of acute respiratory infections. Yinqiaosan, originally described in the *Wen Bing Tiao Bian*, is composed of herbs like Lonicerae Japonicae Flos and Forsythiae Fructus, primarily aimed at resolving exterior wind-heat syndromes. Maxingganshitang, from the *Shang Han Lun*, consists of Ephedrae Herba, Armeniacae Semen Amarum, Gypsum Fibrosum, and Glycyrrhizae Radix et Rhizoma, and is traditionally used to clear lung heat and relieve cough and wheezing. Together, this combination is frequently prescribed for viral pneumonia, influenza, and COVID-19. Its pharmacological effects include broad-spectrum antiviral activity, significant anti-inflammatory properties through the inhibition of the NF-κB and MAPK signaling pathways, and immunomodulatory effects that help prevent the "cytokine storm" associated with severe respiratory distress.

Other names
Yinqiaosan and Maxingshigan decoctionYQS-MXG STYin Qiao San plus Ma Xing Gan Shi TangSilver Powder and Ephedra, Apricot Kernel, Gypsum and Licorice Decoction
02

Targets

IL-6 (Interleukin 6)NeuraminidaseTLR4 (Toll-like receptor 4)

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