Drug intelligence / Profile preview

Yiqi Yangxue decoction + cisplatin + gemcitabine

Development stage
Unknown
Lead developer
Michigan State University
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

The combination of Yiqi Yangxue decoction with cisplatin and gemcitabine is an integrative treatment approach for non-small cell lung cancer (NSCLC) patients, blending traditional Chinese medicine (TCM) with conventional chemotherapy. Yiqi Yangxue decoction, a traditional Chinese medicine formula, is administered alongside standard chemotherapy (cisplatin and gemcitabine), typically once per day starting from the first day of chemotherapy. Clinical studies indicate that this combination can effectively reduce serum tumor marker levels, enhance the body's immune function, improve sleep quality, and mitigate chemotherapy-induced toxic side effects such as gastrointestinal reactions, leukopenia, anemia, and neurotoxicity. This combination therapy is primarily indicated for postoperative NSCLC patients, aiming to promote rapid recovery post-surgery while enhancing chemotherapy efficacy and reducing toxicity. The Yiqi Yangxue decoction itself consists of multiple herbs and is based on TCM theory, which posits that tumor development relates to a patient's "positive qi" condition, with weak "positive qi" being a contributing factor. This combination represents an integrative approach to cancer treatment, combining elements of traditional Chinese medicine with modern Western medical practices.

02

Targets

DNA polymerase familyDNA

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