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zanubrutinib + BEAM
- Development stage
- Phase 2
- Lead developer
- BeiGene
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Zanubrutinib + BEAM is a combination regimen consisting of the small molecule Bruton tyrosine kinase inhibitor zanubrutinib and the high-dose chemotherapy conditioning protocol known as BEAM. Zanubrutinib selectively inhibits Bruton tyrosine kinase, disrupting B-cell receptor signaling and leading to apoptosis in malignant B cells. The BEAM regimen includes four chemotherapeutic agents—carmustine (BCNU), etoposide, cytarabine, and melphalan—used primarily as a conditioning treatment before autologous stem cell transplantation in lymphoma patients. This combination is being explored for relapsed or refractory lymphomas to enhance anti-tumor efficacy prior to stem cell transplant[5][6][8].
- Other names
- BCNU/etoposide/cytarabine/melphalancarmustine/etoposide/cytarabine/melphalan
02
Targets
BTK (Bruton tyrosine kinase)DNADNA polymerase familyTOP2A (DNA topoisomerase II)
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