Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
zeprumetostat + fuzuloparib
- Development stage
- Phase 2
- Lead developer
- Hengrui Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zeprumetostat + fuzuloparib is a combination therapy comprising an EZH2 inhibitor and a PARP inhibitor, currently under investigation for the treatment of advanced or recurrent ovarian epithelial carcinoma. Zeprumetostat (SHR2554) is a small molecule that selectively inhibits the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2), thereby reversing epigenetic silencing of tumor suppressor genes. Fuzuloparib (SHR3162) is a potent inhibitor of Poly (ADP-ribose) polymerase (PARP) 1 and 2, which are critical for the repair of single-strand DNA breaks. By combining these two agents, the therapy aims to induce synthetic lethality and overcome resistance mechanisms in ovarian cancer cells. This specific clinical trial is being conducted by Peking University Third Hospital using agents developed by Jiangsu Hengrui Pharmaceuticals.
- Other names
- Zeprumetostat and Fuzuloparib combination
02
Targets
EZH2 (Histone-lysine N-methyltransferase EZH2)PARP1 (Poly (adp-ribose) polymerase 1)Pol II (RNA polymerase II elongation factors)
Beyond the preview
Go deeper on zeprumetostat + fuzuloparib.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on zeprumetostat + fuzuloparib.