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Zhilong Huoxue Tongyu is a Traditional Chinese Medicine (TCM) formulation, typically administered in capsule form, developed for the treatment of stable angina pectoris in patients with coronary heart disease (CHD). It is specifically indicated for the TCM phenotype of "Qi deficiency and blood stasis syndrome." The formulation's name suggests the inclusion of animal-derived components such as *Hirudo* (Shuizhi/Leech) and *Pheretima* (Dilong/Earthworm), which are traditionally used to promote blood circulation, resolve stasis, and improve microcirculation. The drug is currently being evaluated in Phase 2 clinical trials that utilize LC-MS metabolomics to analyze metabolic changes in serum, urine, and feces, aiming to provide a molecular basis for its therapeutic efficacy in cardiovascular disease.
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