zhizi + chuanxiong

Zhizi + chuanxiong is a traditional Chinese medicine (TCM) herbal combination consisting of Zhizi (Fructus Gardeniae) and Chuanxiong (Ligusticum chuanxiong). This herb pair is used primarily for cardiovascular protection, especially in the context of atherosclerosis. Mechanistically, studies indicate that the combination exerts anti-atherosclerotic effects by suppressing inflammatory pathways—specifically inhibiting the TNF/NF-κB axis and reducing M1 macrophage polarization. Experimental data show that it can decrease intima-media thickness, plaque area, serum lipid levels, and markers of inflammation such as TNF-α and IL-1β in animal models. In TCM theory, Zhizi clears heat and dampness while Chuanxiong promotes blood circulation and relieves blood stasis; together they are believed to synergize for enhanced efficacy against vascular inflammation[1][3][2][4].

Other names

zhizi chuanxiong herb pairZCHPZhizi Chuanxiong Capsule