Drug intelligence / Profile preview

zidovudine + lamivudine + indinavir + ritonavir

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination antiretroviral therapy regimen consisting of four drugs used for the treatment of HIV-1 infection. It combines two nucleoside reverse transcriptase inhibitors (zidovudine and lamivudine) with two protease inhibitors (indinavir and ritonavir). This combination therapy works by inhibiting different stages of the HIV replication cycle, with zidovudine and lamivudine inhibiting the reverse transcriptase enzyme, while indinavir and ritonavir inhibit the viral protease enzyme. The combination has shown effectiveness in suppressing HIV viral load and increasing CD4 cell counts in patients with HIV infection.

02

Targets

Human immunodeficiency virus type 1 reverse transcriptasePR (Progesterone receptor)

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