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zimberelimab + chemotherapy
- Development stage
- Unknown
- Lead developer
- Guangzhou Gloria Biosciences
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**Zimberelimab + chemotherapy** is a combination therapy being investigated primarily for cancer treatment, particularly in advanced gastric and gastroesophageal junction adenocarcinoma with elevated AFP and negative HER2 status. Zimberelimab (GLS-010) is a fully human monoclonal IgG4 antibody directed against the PD-1 receptor, functioning as an immune checkpoint inhibitor to restore T-cell activity and promote anti-tumor immunity. As a combination, it is typically administered with standard chemotherapeutic regimens such as XELOX (oxaliplatin + capecitabine) and is also studied with agents like lenvatinib, a multi-tyrosine kinase inhibitor. The primary mechanism of zimberelimab is blockade of PD-1, preventing its interaction with PD-L1/2, thus reversing T-cell suppression in the tumor microenvironment.
- Other names
- zimberelimab + chemotherapyGLS-010 + chemotherapy
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)DNATS (Thymidylate synthase)
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