Drug intelligence / Profile preview

zinc oxide + betamethasone dipropionate + petrolatum + menthol + clotrimazole

Development stage
Unknown
Lead developer
Puretek
Modality
Small Molecules
Administration
Topical
01

Overview

This is a topical **combination drug** containing zinc oxide, betamethasone dipropionate, petrolatum, menthol, and clotrimazole. It is formulated for the treatment and symptomatic relief of **inflammatory and fungal skin conditions**, particularly those presenting with a combination of infection, inflammation, itching, and minor skin irritation. - **Zinc oxide** acts as a topical protectant and mild antiseptic, forming a barrier on the skin to prevent wetness and irritation and to promote healing[2][4][6][12]. - **Betamethasone dipropionate** is a potent synthetic glucocorticoid corticosteroid; it reduces inflammation, itching, and redness by suppressing local inflammatory responses[9][13][15][1]. - **Clotrimazole** is an azole antifungal that inhibits the biosynthesis of ergosterol, a key component of fungal cell membranes, thus exhibiting fungistatic and fungicidal actions[9][11][13][15][16]. - **Menthol** provides a local cooling and anti-pruritic effect, relieving itching and minor pain[8]. - **Petrolatum** acts as an occlusive moisturizer, helping protect and hydrate the skin. Such combinations are typically used for eczematous, irritant, or fungal skin infections such as tinea, ringworm, intertrigo, and inflamed dermatitis, particularly when oozing, pruritus, and secondary infections are present. This specific five-ingredient combination is not widely available under a unique brand or code name but its individual components and related formulas are established in dermatological care.

Brand names
CLOBEZIN
Other names
petrolatum + zinc oxide + clotrimazole + menthol + betamethasone dipropionateclotrimazole + betamethasone dipropionate cream + menthol + petrolatum + zinc oxide paste
02

Targets

GR (Glucocorticoid receptor)CYP51A1 (Sterol 14α-demethylase)

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