Drug intelligence / Profile preview

zinc oxide + miconazole nitrate + trolamine

Development stage
Unknown
Lead developer
Stiefel
Modality
Small Molecules
Administration
Topical
01

Overview

A topical multi-ingredient formulation combining **zinc oxide**, **miconazole nitrate**, and **trolamine**. Zinc oxide is a skin protectant and mild astringent; miconazole nitrate is an imidazole antifungal that inhibits ergosterol biosynthesis in fungal cell membranes, particularly effective against Candida species; trolamine acts as an emulsifying and buffering agent. This combination is typically used for adjunctive treatment of diaper dermatitis (diaper rash) when complicated by documented candidiasis (fungal infection) in pediatric patients[1][2][3][4][5]. The cream forms a barrier protecting skin, while the antifungal eliminates fungal overgrowth.

02

Targets

CYP51A1 (Sterol 14α-demethylase)

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