Drug intelligence / Profile preview

zinc sulfate + cupric sulfate + manganese sulfate + selenious acid

Development stage
Approved
Lead developer
American Regent
Modality
Small Molecules
Administration
Intravenous, Parenteral
01

Overview

This drug is a combination of four essential trace elements—zinc sulfate, cupric sulfate, manganese sulfate, and selenious acid—formulated for intravenous administration as a supplement to parenteral nutrition (PN). It is indicated for adult and pediatric patients, including neonates, who require long-term parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. Each component serves as a critical cofactor for various metabolic processes: zinc is essential for protein synthesis and cell division; copper is a cofactor for enzymes like cytochrome c oxidase; manganese activates enzymes such as decarboxylases and kinases; and selenium is a component of glutathione peroxidase, which protects cells from oxidative stress. The combination was developed to provide a standardized source of these elements, reducing the risk of contamination and dosing errors associated with manual compounding of individual trace elements.

Brand names
TralementMultrys
Other names
Trace Elements Injection 4Zinc, Copper, Manganese, and Selenium Injection
02

Targets

COX7C (Cytochrome c oxidase subunit 7C, mitochondrial)TXNRD2 (Thioredoxin reductase 2)PROC (Protein C)GPX4 (Glutathione peroxidase 4)15-LOX (Lysyl Oxidase)ARG1 (Arginase 1)Misfolded SOD1

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